If you're searching for a 2016 Mercedes-Benz S-Class S 550 4MATIC for sale in Detroit, MI, your search ends here. Best of Michigan Auto Sales has this iconic full-size luxury sedan in stock and ready for a test drive. With its twin-turbocharged V8 engine, all-wheel drive capability, and a cabin that defines what a flagship luxury car should feel like, this S 550 4MATIC represents one of the most sophisticated driving experiences available at any price point — let alone at the pre-owned market value this generation commands today.
 

About This 2016 Mercedes-Benz S-Class S 550 4MATIC

The W222-generation S-Class was widely praised by automotive journalists as one of the best cars in the world when it launched, and the 2016 model year sits squarely in the sweet spot of that generation's refinement cycle. This particular example carries 131,567 miles on the odometer — a number that tells the story of a well-used vehicle, but one that, in the context of the S-Class's legendary build quality and engineering longevity, remains very much drivable and enjoyable. Buyers comfortable with proper maintenance history and pre-purchase inspections will find tremendous value in a well-kept S 550 at this mileage tier. The S-Class is built to last well beyond 200,000 miles when cared for, and this one is priced to reflect its real-world condition as a used luxury flagship.
 

2016 Mercedes-Benz S-Class Performance and Engine

At the heart of this S 550 4MATIC is Mercedes-Benz's legendary twin-turbocharged 4.7-liter V8 engine — a powerplant that produces around 449 horsepower and 516 lb-ft of torque in this application. Paired with a 7-speed adaptive sport automatic transmission, this drivetrain delivers effortless, confident acceleration whether you're merging onto I-75 or cruising down Woodward Avenue. The shift logic adapts to your driving style, holding gears during spirited driving and softening transitions during relaxed cruising.
 

4MATIC All-Wheel Drive for Michigan Driving Conditions

The 4MATIC all-wheel drive system is more than a performance feature — it's a genuine practical advantage for Michigan winters. Detroit, Wayne County, and the greater southeastern Michigan region see significant snow accumulation and icy road conditions from November through March. The S 550 4MATIC distributes torque to all four wheels seamlessly, giving you the traction of a German luxury AWD system without sacrificing any of the ride quality that makes the S-Class what it is.
 

Mercedes-Benz S-Class Features and Interior

The S 550 trim places you at the top tier of the standard S-Class lineup, well above the entry-level S 500 and loaded with technology that was genuinely ahead of its time in 2016. Expect features including the dual 12.3-inch widescreen display spanning the instrument cluster and infotainment screen, a Burmester surround sound audio system, massaging multi-contour front seats, ambient lighting with 64 color options, and a panoramic sunroof. The Airmatic air suspension system comes standard and provides a magic-carpet ride quality that remains unmatched in the segment.
 

Technology and Driver Assistance

The 2016 S-Class was equipped with a suite of driver assistance features that many vehicles still haven't matched — including Active Lane Keeping Assist, Attention Assist, Distronic Plus adaptive cruise control with stop-and-go capability, and the Pre-Safe collision mitigation system. The COMAND infotainment system offers navigation, Bluetooth connectivity, and smartphone integration in a package that still feels intuitive and usable today.
 

Mercedes-Benz S-Class Reliability and Ownership

The W222 S-Class has a nuanced ownership profile that buyers should understand going in. Mercedes-Benz engineered this car for outright excellence rather than low running costs, and the maintenance and repair expenses reflect that. Common ownership considerations at higher mileage include the air suspension components, ABC hydraulic system maintenance, battery replacement (it uses dual batteries), and regular servicing of the seven-speed transmission fluid. Independent Mercedes-Benz specialists in the Detroit metro area — including shops in Dearborn, Southfield, and Royal Oak — can handle this vehicle at significantly lower labor rates than franchise dealers, making ownership far more manageable. Buyers who approach this car with eyes open and a relationship with a qualified independent shop typically have excellent long-term experiences.
 

Why Buy From Best of Michigan Auto Sales in Detroit, MI

Best of Michigan Auto Sales is located in Detroit, in the heart of Wayne County, and has built its reputation serving real buyers throughout southeastern Michigan. As an independent pre-owned dealer, Best of Michigan Auto Sales offers straightforward pricing and a hands-on buying experience that larger volume stores simply can't match. The team understands the Detroit market, the buyers who live here, and what it takes to earn long-term trust. When you're purchasing a high-value luxury vehicle like the S-Class, working with a dealer who takes the time to answer your questions and stand behind their inventory matters. Stop in, walk around the car, and see for yourself.
 

Financing a Used Mercedes-Benz S-Class Near Detroit

Financing a pre-owned luxury vehicle in the Detroit area is more accessible than many buyers realize. Best of Michigan Auto Sales works with a range of lending partners to help buyers across the credit spectrum — whether your credit is excellent, fair, or you're rebuilding after a setback. A used S 550 at this price point can often fit within a monthly budget that might surprise you, especially when spread across a 48- or 60-month term. Bring your questions about rates, down payments, and trade-in value when you visit. The team at Best of Michigan Auto Sales in Detroit, Wayne County, is here to make the numbers work.
 

Frequently Asked Questions

Is the 2016 Mercedes-Benz S-Class S 550 a good used car buy?

For buyers who want the absolute pinnacle of luxury driving experience at a fraction of the original MSRP — which was well over $100,000 new — yes, the 2016 S 550 is a compelling used buy. The key is going in with realistic expectations about maintenance costs and ensuring the vehicle has a documented service history. In the right hands, it's an extraordinary car.
 

How many miles is too many on a used Mercedes-Benz S-Class?

The S-Class is engineered for longevity, and examples with 150,000 to even 200,000 miles are not uncommon among enthusiast owners who maintain them properly. At 131,567 miles, this S 550 is in the higher-mileage used luxury segment, but it is by no means at the end of its life. A pre-purchase inspection by a qualified Mercedes-Benz technician is strongly recommended at any mileage level.
 

What does the S 550 4MATIC trim include over other S-Class trims?

The S 550 designation identifies the twin-turbo 4.7-liter V8 powertrain, placing it above the inline-six-powered S 450 and below the AMG variants. The 4MATIC suffix confirms the all-wheel drive system. At the S 550 trim, buyers receive a comprehensive standard feature set including the Airmatic air suspension, dual widescreen display, Burmester audio, and a long list of advanced driver assistance technologies.
 

Is the 2016 Mercedes-Benz S-Class good in snow and winter driving?

The 4MATIC all-wheel drive system makes this S-Class genuinely capable in Michigan winter conditions. Paired with winter tires, the S 550 4MATIC handles snow and ice far better than rear-wheel drive luxury competitors. The low ground clearance limits deep snow performance, but for typical Detroit metro winter driving, it performs very well.
 

What should I check before buying a high-mileage S-Class?

Key items to inspect include the Airmatic air suspension (listen for compressor noise, check for sag), transmission fluid condition, both auxiliary and main battery health, brake pad and rotor wear, and any active fault codes via a diagnostic scan. Also verify coolant system condition and look for any oil leaks from the valve cover gaskets, which are common at higher mileage on the M278 V8 engine.
 

Serving Detroit and Surrounding Areas in Wayne County

Best of Michigan Auto Sales proudly serves buyers throughout Detroit and the broader Wayne County region, including customers traveling in from Dearborn, Livonia, Lincoln Park, Wyandotte, Taylor, Inkster, Garden City, and Westland. Buyers from neighboring Oakland and Macomb County communities — including Warren, Sterling Heights, and Troy — regularly make the drive to Detroit for the right vehicle at the right price. If you're searching for a used S-Class near southeastern Michigan, this listing is worth the trip.
 

Contact Best of Michigan Auto Sales Today

Don't let this 2016 Mercedes-Benz S-Class S 550 4MATIC sit on the lot while you're still thinking about it. Inventory at this price point moves quickly. Call Best of Michigan Auto Sales in Detroit, MI at 313-499-8335 to confirm availability, ask questions, or schedule a test drive at a time that works for you. The team is ready to help you get behind the wheel of one of the finest luxury sedans ever built — at a price that makes real-world ownership possible.